Environmental Policy And Firm Relocation: The Case Of U.S.-Mexico

The paper studies the effect of stringent environmental policy on domestic firms' location decisions, especially in the context of a bilateral trade agreement. The main variables included are market size, trade barriers, and fixed costs of establishing abroad. The results show that parameter assumption in the inverse demand function matter. In addition, changes in model variables yield both intuitive and some less intuitive results. For example, predictions on firm movement following economic integration are not as clear as might be expected. The results are discussed in the context of U.S.-Mexico economic integration.

A possible role of ground-based microorganisms on cloud formation in the atmosphere

The formation of clouds is an important process for the atmosphere, the hydrological cycle, and climate, but some aspects of it are not completely understood. In this work, we show that microorganisms might affect cloud formation without leaving the Earth's surface by releasing biological surfactants (or biosurfactants) in the environment, that make their way into atmospheric aerosols and could significantly enhance their activation into cloud droplets. <br><br> In the first part of this work, the cloud-nucleating efficiency of standard biosurfactants was characterized and found to be better than that of any aerosol material studied so far, including inorganic salts. These results identify molecular structures that give organic compounds exceptional cloud-nucleating properties. In the second part, atmospheric aerosols were sampled at different locations: a temperate coastal site, a marine site, a temperate forest, and a tropical forest. Their surface tension was measured and found to be below 30 mN/m, the lowest reported for aerosols, to our knowledge. This very low surface tension was attributed to the presence of biosurfactants, the only natural substances able to reach to such low values. <br><br> The presence of strong microbial surfactants in aerosols would be consistent with the organic fractions of exceptional cloud-nucleating efficiency recently found in aerosols, and with the correlations between algae bloom and cloud cover reported in the Southern Ocean. The results of this work also suggest that biosurfactants might be common in aerosols and thus of global relevance. If this is confirmed, a new role for microorganisms on the atmosphere and climate could be identified

A Feedforward Neural Network Approach for the Detection of Optically Thin Cirrus From IASI-NG

The identification of optically thin cirrus is crucial for their accurate parameterization in climate and Earth's system models. This study exploits the characteristics of the infrared atmospheric sounding interferometer-new generation (IASI-NG) to develop an algorithm for the detection of optically thin cirrus. IASI-NG has been designed for the European Organization for the Exploitation of Meteorological Satellites (EUMETSAT) polar system second-generation program to continue the service of its predecessor IASI from 2024 onward. A thin-cirrus detection algorithm (TCDA) is presented here, as developed for IASI-NG, but also in parallel for IASI to evaluate its performance on currently available real observations. TCDA uses a feedforward neural network (NN) approach to detect thin cirrus eventually misidentified as clear sky by a previously applied cloud detection algorithm. TCDA also estimates the uncertainty of "clear-sky" or "thin-cirrus" detection. NN is trained and tested on a dataset of IASI-NG (or IASI) simulations obtained by processing ECMWF 5-generation reanalysis (ERA5) data with the s-IASI radiative transfer model. TCDA validation against an independent simulated dataset provides a quantitative statistical assessment of the improvements brought by IASI-NG with respect to IASI. In fact, IASI-NG TCDA outperforms IASI TCDA by 3% in probability of detection (POD), 1% in bias, and 2% in accuracy, and the false alarm ratio (FAR) passes from 0.02 to 0.01. Moreover, IASI TCDA validation against state-of-the-art cloud products from Cloudsat/CPR and CALIPSO/Cloud-Aerosol Lidar with Orthogonal Polarization (CALIOP) real observations reveals a tendency for IASI TCDA to underestimate the presence of thin cirrus (POD = 0.47) but with a low FAR (0.07), which drops to 0.0 for very thin cirrus

Cross-country catch-up in the manufacturing sector: Impacts of heterogeneity on convergence and technology adoption

Abstract This paper analyses econometrically the relationship between productivity growth in manufacturing and technology transfer from the leading economy. The recent convergence literature identifies two processes required for convergence; nations must both attain comparable levels of factor intensity and similar levels of technology. Homogeneity in technologies has neither theoretical nor empirical support. The paper focuses on the manufacturing sector and its two-digit industries while allowing for heterogeneity in technology and in the rate of catch-up. It compares catch-up rates and productivity estimates across manufacturing sectors and GDP and discusses possible sources for the obtained differences. The empirical part of the paper explores the validity of our econometric model for 16 OECD countries for aggregate and manufacturing labor productivity. Our results indicate that aggregate studies bias downward the estimated convergence rates. The rates of catch-up, as well as levels of productivity and sources of its growth in terms of technology and efficiency growth, also differ across countries. Finally, it finds that institutional factors such as bureaucratic efficiency are important determinants of catch-up rates

Spectrum Synergy for Investigating Cloud Microphysics

Observations from spaceborne microwave (MW) and infrared (IR) passive sensors are the backbone of current satellite meteorology, essential for data assimilation into modern numerical weather prediction and for climate benchmarking. While MW and IR observations from space offer complementary features with respect to cloud properties, their synergy for cloud investigation is currently underexplored, despite the presence of both MW and IR sensors on operational meteorological satellites such as the EUMETSAT Polar System (EPS) MetOp series. As such, several key cloud microphysical properties are not part of the operational products available from EPS MetOp sensors. In addition, the EPS Second Generation (EPS-SG) series, scheduled for launch starting from 2024 onward, will carry sensors such as the Microwave Sounder (MWS) and IASI Next Generation (IASI-NG), enhancing spatial and spectral resolutions and thus capacity to retrieve cloud properties. This article presents the Combined MWS and IASI-NG Soundings for Cloud Properties (ComboCloud) project, funded by EUMETSAT with the overall objective to specify, prototype, and validate algorithms for the retrieval of cloud microphysical properties (e.g., water content and drop effective radius) from the synergy of passive MW and IR observations. The article presents the synergy rationale, the algorithm design, and the results obtained exploiting simulated observations from EPS and EPS-SG sensors, quantifying the benefits to be expected from the MW-IR synergy and the new generation sensors

The Quantification of Muscle Activation during the Loaded Carry Movement Pattern

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Coordinated and tailored work rehabilitation: a randomized controlled trial with economic evaluation undertaken with workers on sick leave due to musculoskeletal disorders

Introduction In Denmark, the magnitude and impact of work disability on the individual worker and society has prompted the development of a new "coordinated and tailored work rehabilitation" (CTWR) approach. The aim of this study was to compare the effects of CTWR with conventional case management (CCM) on return-to-work of workers on sick leave due to musculoskeletal disorders (MSDs). Methods The study was a randomized controlled trial with economic evaluation undertaken with workers on sick leave for 4-12 weeks due to MSDs. CTWR consists of a work disability screening by an interdisciplinary team followed by the collaborative development of a RTW plan. The primary outcome variable was registered cumulative sickness absence hours during 12 months follow-up. Secondary outcomes were work status as well as pain intensity and functional disability, measured at baseline, 3 and 12 months follow-up. The economic evaluation (intervention costs, productivity loss, and health care utilization costs) was based on administrative data derived from national registries. Results For the time intervals 0-6 months, 6-12 months, and the entire follow-up period, the number of sickness absence hours was significantly lower in the CTWR group as compared to the control group. The total costs saved in CTWR participants compared to controls were estimated at US $1,366 per person at 6 months follow-up and US$ 10,666 per person at 12 months follow-up. Conclusions Workers on sick leave for 4-12 weeks due to MSD who underwent "CTWR" by an interdisciplinary team had fewer sickness absence hours than controls. The economic evaluation showed that-in terms of productivity loss-CTWR seems to be cost saving for the society

Analog Computer Research

Contains reports on two research projects

Production, characterization, and antigen specificity of recombinant 62-71-3, a candidate monoclonal antibody for rabies prophylaxis in humans

Rabies kills many people throughout the developing world every year. The murine monoclonal antibody (mAb) 62-71-3 was recently identified for its potential application in rabies postexposure prophylaxis (PEP). The purpose here was to establish a plant-based production system for a chimeric mouse-human version of mAb 62-71-3, to characterize the recombinant antibody and investigate at a molecular level its interaction with rabies virus glycoprotein. Chimeric 62-71-3 was successfully expressed in Nicotiana benthamiana. Glycosylation was analyzed by mass spectroscopy; functionality was confirmed by antigen ELISA, as well as rabies and pseudotype virus neutralization. Epitope characterization was performed using pseudotype virus expressing mutagenized rabies glycoproteins. Purified mAb demonstrated potent viral neutralization at 500 IU/mg. A critical role for antigenic site I of the glycoprotein, as well as for two specific amino acid residues (K226 and G229) within site I, was identified with regard to mAb 62-71-3 neutralization. Pseudotype viruses expressing glycoprotein from lyssaviruses known not to be neutralized by this antibody were the controls. The results provide the molecular rationale for developing 62-71-3 mAb for rabies PEP; they also establish the basis for developing an inexpensive plant-based antibody product to benefit low-income families in developing countries.—Both, L., van Dolleweerd, C., Wright, E., Banyard, A. C., Bulmer-Thomas, B., Selden, D., Altmann, F., Fooks, A. R., Ma, J. K.-C. Production, characterization, and antigen specificity of recombinant 62-71-3, a candidate monoclonal antibody for rabies prophylaxis in humans